Joaquim Roca
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Joaquim Roca | |
|---|---|
| Born | 1960 Barcelona |
| Scientific career | |
| Fields | Molecular biology |
| Institutions |
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Joaquim Roca is a Spanish biomedical scientist who serves as Research Professor at the Spanish National Research Council (CSIC) and head of the DNA Topology Laboratory at the Institute of Molecular Biology of Barcelona (IBMB).[1][2][3] Roca graduated in Medicine from the University of Barcelona in 1983 and earned a PhD from the same university in 1988.[4][5] He received postdoctoral training (1988–1991) and worked as a research associate (1992–1996) in the laboratory of James C. Wang at Harvard University. He joined the IBMB in 1997.[4][5][1]
His research centered on uncovering the DNA transport mechanism of Topoisomerases and how these enzymes modulate the helical tension and entanglement of DNA within biological systems. He also developed DNA electrophoresis and high-throughput sequencing approaches to decipher the DNA topology at local and genome-wide scales. [5][6][7]
Selected works
- Roca, Joaquim; Wang, James C. (27 November 1992). "The capture of a DNA double helix by an ATP-dependent protein clamp: a key step in DNA transport by type II DNA topoisomerases". Cell. 71 (5): 833–840. doi:10.1016/0092-8674(92)90558-t. PMID 1330327.
- Roca, Joaquim; Wang, James C. (20 May 1994). "DNA transport by a type II DNA topoisomerase: evidence in favor of a two-gate mechanism". Cell. 77 (4): 609–616. doi:10.1016/0092-8674(94)90222-4. PMID 8187179.
- Roca, Joaquim (April 1995). "The mechanisms of DNA topoisomerases". Trends in Biochemical Sciences. 20 (4): 156–160. doi:10.1016/s0968-0004(00)88993-8. PMID 7770916.
- Roca, Joaquim (2009-02-01). "Topoisomerase II: a fitted mechanism for the chromatin landscape". Nucleic Acids Research. 37 (3): 721–730. doi:10.1093/nar/gkn994.
- Roca, Joaquim (2011). "The torsional state of DNA within the chromosome". Chromosoma. 120: 323–334. doi:10.1007/s00412-011-0324-y.
References
- ↑ 1.0 1.1 "CSIC-Digital". Retrieved 2025-12-10.
- ↑ "CSIC-Labs". Retrieved 2025-12-20.
- ↑ "IBMB-DNA Topology Lab". Retrieved 2025-12-20.
- ↑ 4.0 4.1 "IBMB–Roca". Retrieved 2025-12-10.
- ↑ 5.0 5.1 5.2 "Joaquim Roca ORCID". Retrieved 2025-12-10.
- ↑ "Roca SCHOLAR". Retrieved 2025-12-10.
- ↑ "Roca PubMED". Retrieved 2025-12-10.
External links
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